The intensity of action is directly related to the degree of benzodiazepine receptor occupancy.Intravenous or intramuscular administration of the recommended dose of 2 mg to 4 mg of Ativan Injection to adult patients is followed by dose-related effects of sedation (sleepiness or drowsiness), relief of preoperative anxiety, and lack of recall of events related to the day of surgery in the majority of patients.The clinical sedation (sleepiness or drowsiness) thus noted is such that the majority of patients are able to respond to simple instructions whether they give the appearance of being awake or asleep.
Is ativan injection use for sedating
This interaction is presumed to be responsible for lorazepam’s mechanism of action.
Lorazepam exhibits relatively high and specific affinity for its recognition site but does not displace GABA.
Attachment to the specific binding site enhances the affinity of GABA for its receptor site on the same receptor complex.
The pharmacodynamic consequences of benzodiazepine agonist actions include antianxiety effects, sedation, and reduction of seizure activity.
The majority of patients under these reinforced conditions had difficulty recalling perioperative events or recognizing props from before surgery.
The lack of recall and recognition was optimum within 2 hours following intramuscular administration and 15 to 20 minutes after intravenous injection.
The intended effects of the recommended adult dose of Ativan Injection usually last 6 to 8 hours.
Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.
It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2 Lorazepam is a nearly white powder almost insoluble in water.
Each m L of sterile injection contains either 2.0 or 4.0 mg of lorazepam, 0.18 m L polyethylene glycol 400 in propylene glycol with 2.0% benzyl alcohol as preservative.
Lorazepam interacts with the γ-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is widespread in the brain of humans as well as other species.